CAS號: 34580-14-8

運用：用于蕁麻疹、瘙癢癥、濕疹、過敏性皮炎、特應性皮炎、神經(jīng)性皮炎等過敏性疾病;近期報道治療硬皮病有效，對支氣管哮喘有很好的療效，對過敏性哮喘療效顯著，混合型次之，感染型約半數(shù)有效，對哮喘有預防作用

副作用：The biggest side effect of ketotefen is somnolence or fatigue and weakness. This side effect is more obvious in adults and is one of the main reasons for the limitation of clinical use. The somnolence or fatigue can reduce the living quality of asthma and children's asthma. Usually, after 1-4 weeks of continuous administration, the side effects of central nerve suppression can be significantly reduced or even gradually disappeared. The clinical observation showed that the combination of theophylline and theophylline could reduce the central nervous inhibition of ketotefen, and counteract the central nerve excitability of theophylline, but the synergistic anti-inflammatory effect needed further observation. Clinical observations confirm that children usually do not have a significant central neurologic inhibitory effect on ketotefen, which can only cause inattention in children. Even if the dose is given to adults, the mechanism is not b. Wood and other clinical observations of two years of continuous oral administration of asthma and children's asthma confirmed that the long-term use of ketotefen did not have other serious side effects and had no effect on the liver, renal function and peripheral blood cell count, and it was not susceptible to resistance. Generally, after six weeks of continuous oral Administration of fumaric acid ketotefen, it could start to compete. Bronchial spasmodic or glucocorticoids were gradually reduced, and no rebound phenomenon was observed after long term treatment. Therefore, the comprehensive buation of the drug is that ketotefen is a kind of central nervous inhibition (the side effect can be adapted gradually), relatively safe and effective, with a certain anti inflammatory properties, low price antiasthmatic drugs. Since FDA has not been approved so far, it should be used cautiously in clinical practice.